When does obesity exert its effect in conferring risk of developing RA: a large study in cohorts of symptomatic persons at risk.
Quirine A DumoulinAnna M P BoerenDoortje Isabelle KrijbolderA WillemzePascal Hendrik Pieter de JongElise van MulligenHanna W van SteenbergenAnnette H M van der Helm van MilPublished in: RMD open (2024)
Obesity is not associated with RA development within CSA patients but BMI has already increased in CSA compared to the general population. Obesity, therefore, presumably exerts its risk effect at an early asymptomatic phase of RA development, rather than being associated with the disease processes that ultimately result in clinical arthritis.
Keyphrases
- rheumatoid arthritis
- insulin resistance
- metabolic syndrome
- weight loss
- weight gain
- high fat diet induced
- type diabetes
- end stage renal disease
- disease activity
- ejection fraction
- newly diagnosed
- body mass index
- ankylosing spondylitis
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- adipose tissue
- skeletal muscle
- systemic sclerosis