NOP receptor antagonism reduces alcohol drinking in male and female rats through mechanisms involving the central amygdala and ventral tegmental area.
Anna Maria BorrutoYannick FotioSerena StopponiGloria BrunoriMichele PetrellaFrancesca Felicia CaputiPatrizia RomualdiSanzio CandelettiRajesh NarendranLinda M Rorick-KehnMassimo UbaldiFriedbert WeissRoberto CiccocioppoPublished in: British journal of pharmacology (2020)
The present results revealed that the CeA and VTA are neuroanatomical substrates that mediate the effects of NOP receptor antagonism on alcohol consumption. Overall, our findings support the potential of NOP receptor antagonism as a treatment strategy to attenuate alcohol use and addiction.