Efficacy and safety of lithium and lamotrigine for the maintenance treatment of clinically stable patients with bipolar disorder: A systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials with an enrichment design.

Kazuto OyaKenji SakumaSatoru EsumiYasuhiko HashimotoMasakazu HatanoYuki MatsudaYuki MatsuiNobumi MiyakeIkuo NomuraMakoto OkuyaNakao IwataMasaki KatoRyota HashimotoKazuo MishimaNorio WatanabeTaro Kishi

Published in: Neuropsychopharmacology reports (2019)

Both drugs showed benefit for preventing relapse in clinically stable patients with adult BD. However, the number of studies and patients in this analysis was small.

Keyphrases

placebo controlled
double blind
bipolar disorder
phase iii
clinical trial
phase ii
end stage renal disease
ejection fraction
newly diagnosed
study protocol
peritoneal dialysis
phase ii study
prognostic factors
patient reported outcomes
radiation therapy
rectal cancer
drug induced
combination therapy