Combined scRNAseq and Bulk RNAseq Analysis to Reveal the Dual Roles of Oxidative Stress-Related Genes in Acute Myeloid Leukemia.

Jing Qi Jingyu Lin Changjiang WuHesheng HeJunping YaoYouhai XuYuqiong YangYuanfeng WeiDongping Huang Yiming Mao

Published in: Oxidative medicine and cellular longevity (2023)

We combined scRNAseq and bulk RNAseq data to construct two different transcriptomic profiles to reveal the different roles of OS-related genes involved in AML oncogenesis and chemotherapy resistance, which might provide important insights into the mechanism of OS-related genes in the pathogenesis and drug resistance of AML.

Keyphrases

acute myeloid leukemia
single cell
oxidative stress
genome wide
allogeneic hematopoietic stem cell transplantation
rna seq
electronic health record
big data
ischemia reperfusion injury
gene expression
squamous cell carcinoma
dna methylation
data analysis
heat stress