Epigenetic methylation in Eosinophilic Esophagitis: Molecular ageing and novel biomarkers for treatment response.

Elizabeth T JensenCarl D LangefeldKip D ZimmermanTimothy D HowardEvan S Dellon

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)

EoE patients that respond versus do not respond to treatment have differences in their methylation profile, including enrichment of genes in pathways consistent with cellular injury and repair due to environmental stress and cell adhesion and barrier integrity. EoE also appears to accelerate cellular ageing. Whether treatment can arrest or reverse accelerated epigenetic ageing and the implications for long-term disease progression is important areas for future research.

Keyphrases

dna methylation
genome wide
cell adhesion
gene expression
ejection fraction
newly diagnosed
cell cycle
cell proliferation
single molecule
replacement therapy
heat stress
climate change
human health
patient reported outcomes