The effect of imatinib administered in the prenatal period on testis development in rats.

Z Topal SuzanLevent TumkayaT MercantepeM AtakH A Uydu

Published in: Human & experimental toxicology (2020)

Our findings show that prenatal exposure to imatinib can lead to histopathological and biochemical changes in testis tissue, but that no adverse effect occurs in nuclear maturation of germ cells during spermiogenesis.

Keyphrases

pregnant women
chronic myeloid leukemia
induced apoptosis
cell cycle arrest
germ cell
signaling pathway
oxidative stress
cell proliferation