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Validation of aminodeoxychorismate synthase and anthranilate synthase as novel targets for bispecific antibiotics inhibiting conserved protein-protein interactions.

Franziska Jasmin FunkeSandra SchleeReinhard Sterner
Published in: Applied and environmental microbiology (2024)
strains to validate two novel targets required for folate and tryptophan biosynthesis that can potentially be targeted by one and the same bispecific protein-protein interaction inhibitor and promise increased robustness against bacterial resistances.
Keyphrases
  • protein protein
  • small molecule
  • escherichia coli
  • signaling pathway
  • transcription factor
  • cancer therapy
  • big data