Antibacterial pyrazoles: tackling resistant bacteria.
Mohammad Abrar AlamPublished in: Future medicinal chemistry (2022)
Bacterial resistance to antibiotics threatens our progress in healthcare, modern medicine, food production and ultimately life expectancy. Antibiotic resistance is a global concern, which spreads rapidly across borders and continents due to rapid travel of people, animals and goods. Derivatives of metabolically stable pyrazole nucleus are known for their wide range of pharmacological properties, including antibacterial activities. This review highlights recent reports of pyrazole derivatives targeting different bacterial strains focusing on the drug-resistant variants. Pyrazole derivatives target different metabolic pathways of both Gram-positive and Gram-negative bacteria.
Keyphrases
- drug resistant
- molecular docking
- multidrug resistant
- healthcare
- acinetobacter baumannii
- gram negative
- structure activity relationship
- escherichia coli
- silver nanoparticles
- emergency department
- copy number
- anti inflammatory
- cancer therapy
- gene expression
- wound healing
- molecular dynamics simulations
- risk assessment
- cystic fibrosis
- dna methylation
- human health
- health information
- social media
- health insurance
- quantum dots