Single-cell analysis identifies distinct CD4+ T cells associated with the pathobiology of pediatric obesity-related asthma.
David A ThompsonYvonne B WabaraSarai DuranAnna ReichenbachLaura ChenKayla ColladoChangsuek YonJohn M GreallyDeepa RastogiPublished in: bioRxiv : the preprint server for biology (2024)
CD4+T cells from obese children with asthma are distinctly programmed for non-allergic immune responses, steroid resistance and inflammasome activation, that underlie the obese asthma phenotype.
Keyphrases
- allergic rhinitis
- chronic obstructive pulmonary disease
- weight loss
- lung function
- metabolic syndrome
- immune response
- type diabetes
- single cell
- adipose tissue
- insulin resistance
- young adults
- rna seq
- air pollution
- genome wide
- high throughput
- cystic fibrosis
- dendritic cells
- inflammatory response
- skeletal muscle
- high fat diet induced
- body mass index