Isavuconazole pharmacokinetics in a patient with cystic fibrosis following bilateral orthotopic lung transplantation.

Published in: Transplant infectious disease : an official journal of the Transplantation Society (2018)

Previous studies of patients with cystic fibrosis (CF) treated with azole antifungals have shown altered pharmacokinetics relative to healthy patients. Data regarding the pharmacokinetic profile of isavuconazole in patients with CF undergoing lung transplantation are currently not available. Serum trough concentrations assessed in a single CF patient following transplant revealed significantly lower values relative to available literature. Larger studies are required to validate CF population pharmacokinetics of isavuconazole.

Keyphrases

cystic fibrosis
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
case report
prognostic factors
peritoneal dialysis
patient reported outcomes
big data
case control
data analysis