Attenuation of adjuvant-induced arthritis with carnosic acid by inhibiting mPGES-1, COX-2, and bone loss in male SD rats.

Shweta ShrivastavaTribhuwan BahugunaSudipto MondalSunil KumarBijo MathewManish Kumar JeengarV G M Naidu

Published in: Immunopharmacology and immunotoxicology (2024)

These findings suggest that CA, through specific enzyme inhibition, offers a compelling alternative therapeutic approach for RA. Further research is warranted to explore the potential of CA in other arthritis models and its suitability for human RA treatment.

Keyphrases

rheumatoid arthritis
bone loss
endothelial cells
disease activity
high glucose
early stage
ankylosing spondylitis
signaling pathway
interstitial lung disease
protein kinase
drug induced
induced pluripotent stem cells
systemic lupus erythematosus
oxidative stress
human health
idiopathic pulmonary fibrosis