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Real-world treatment patterns, healthcare resource utilization and costs among patients with peripheral T-cell lymphoma.

Charles DharmaniSudhir UnniNgan PhamNazneen Fatima ShaikhYan XiongRohan VashiOluwatosin FofahAlessandria StrubingMaribel SalasNora TuMargaret WooddellXiaoyu ZhouAimee M Near
Published in: Future oncology (London, England) (2023)
Objective: To evaluate treatment patterns, healthcare resource utilization (HRU) and costs among peripheral T-cell lymphoma (PTCL) patients in the USA. Methods: A retrospective cohort study, using the IQVIA PharMetrics ® Plus claims database from 1 April 2011 to 30 November 2021, identified PTCL patients receiving systemic treatments. Three mutually exclusive subcohorts were created based on line of therapy (LOT): 1LOT, 2LOT and ≥3LOT. Common treatment regimens, median time on treatment, all-cause and PTCL-related HRU and costs were estimated. Results: Among 189 PTCL patients identified, 61.9% had 1LOT, 21.7% had 2LOT and 16.4% had ≥3LOT. The most common treatment regimens in the 1LOT were CHOP/CHOP-like, CHOEP/CHOEP-like and brentuximab vedotin; monotherapies were most common in the 2LOT and ≥3LOT. All-cause and PTCL-related hospitalizations and prescriptions PPPM increased with increasing LOT. Nearly 70% of total treatment costs were PTCL related. Conclusion: Higher utilization of combination therapies in the 1LOT and monotherapies in subsequent LOTs were observed, alongside high PTCL-related costs.
Keyphrases
  • healthcare
  • end stage renal disease
  • chronic kidney disease
  • stem cells
  • combination therapy
  • ejection fraction
  • prognostic factors
  • drug induced
  • health insurance