Association of Angiotensin II-Stimulating Antihypertensive Use and Dementia Risk: Post Hoc Analysis of the PreDIVA Trial.
Jan Willem van DalenZachary A MarcumShelly L GrayDouglas BartholdEric P Moll van CharanteWillem A van GoolPaul K CraneEric B LarsonEdo RichardPublished in: Neurology (2020)
Users of angiotensin II-stimulating antihypertensives had lower dementia rates compared to angiotensin II-inhibiting antihypertensive users, supporting the angiotensin hypothesis. Confounding by indication must be examined further, although subanalyses suggest this did not influence results. If replicated, dementia prevention could become a compelling indication for older individuals receiving antihypertensive treatment.