Targeting epigenetic features in clear cell sarcomas based on patient-derived cell lines.
Christina KarnerInes AndersDjenana VejzovicJoanna SzkanderaSusanne ScheiplAlexander J A DeutschLarissa WeissKlemens VierlingerDagmar KolbStefan KühbergerEllen HeitzerHansjörg HabischFangrong ZhangTobias MadlBirgit Reininger-GutmannBernadette Liegl-AtzwangerBeate RinnerPublished in: Journal of translational medicine (2023)
MUG Lucifer prim, MUG Lucifer met and isolated and immortalized fibroblasts from the same patient represent an ideal in vitro model to explore the biology of CCS. Based on this cell culture model, novel therapies could be tested in the form of PRMT1 inhibitors, which drive tumor cells into apoptosis, but show no effect on fibroblasts, further supporting their potential as promising treatment options in the combat against CCS. The data substantiate the importance of tailored therapies in the advanced metastatic stage of CCS.
Keyphrases
- clear cell
- extracellular matrix
- oxidative stress
- squamous cell carcinoma
- small cell lung cancer
- dna methylation
- gene expression
- case report
- electronic health record
- cell death
- cell cycle arrest
- high grade
- tyrosine kinase
- big data
- cancer therapy
- smoking cessation
- human health
- risk assessment
- cell proliferation
- pi k akt