The presence of genetic risk variants within PTPN2 and PTPN22 is associated with intestinal microbiota alterations in Swiss IBD cohort patients.

Bahtiyar YilmazMarianne R SpalingerLuc BiedermannYannick FrancNicolas FournierJean-Benoit RosselPascal JuilleratGerhard RoglerAndrew J MacphersonMichael Scharl

Published in: PloS one (2018)

We identified that IBD-associated genetic risk variants, disease severity and the interaction of these factors are related to significant alterations in intestinal microbiota composition of IBD patients.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
copy number
peritoneal dialysis
genome wide
gene expression
patient reported outcomes
ulcerative colitis