Meningeal inflammation and cortical demyelination in acute multiple sclerosis.
Ryan J BevanRhian EvansLauren GriffithsLewis M WatkinsMark I ReesRoberta MagliozziIngrid AllenGavin McDonnellRachel KeeMichelle NaughtonDenise C FitzgeraldRichard ReynoldsJames W NealOwain W HowellPublished in: Annals of neurology (2018)
Our findings demonstrate that cortical demyelination, neuronal loss, and meningeal inflammation are notable pathological hallmarks of acute MS and support the need to identify early biomarkers of this pathology to better predict outcome. Ann Neurol 2018;84:829-842.