Circadian Rhythms Fluctuate the Treatment Effects of Intravesical Treatments on Rat Urinary Frequency Models.

Tomofumi Watanabe Takuya SadahiraYusuke TominagaYuki Maruyama Naoya Nagasaki Takanori SekitoKohei EdamuraToyohiko Watanabe Motoo ArakiMasami Watanabe

Published in: Veterinary medicine international (2024)

The extended monitoring of rat urination by UM-100 revealed a significant fluctuation in the treatment effect of intravesically instilled drugs between day and night. These findings may help establish novel therapies for urinary frequency.

Keyphrases

oxidative stress
single cell
combination therapy
physical activity
drug induced
sleep quality