Exploring disease axes as an alternative to distinct clusters for characterizing sepsis heterogeneity.

Zhongheng ZhangLin ChenXiaoli LiuJie YangJiajie HuangQiling YangQichao HuKetao JinLeo Anthony CeliYucai Hong

Published in: Intensive care medicine (2023)

Cluster analysis of sepsis patients across various cohorts showed modest reproducibility. Sepsis heterogeneity is better characterized through continuous disease axes that coexist to varying degrees within the same individual instead of mutually exclusive subtypes.

Keyphrases

septic shock
acute kidney injury
intensive care unit
end stage renal disease
single cell
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
patient reported