Diminished function of cytotoxic T- and NK- cells in severe alcohol-associated hepatitis.

Adam KimChristina K Cajigas-Du RossJaividhya DasarathyAnnette BellarDavid StreemNicole WelchSrinivasan DasarathyLaura E Nagy

Published in: Metabolism and target organ damage (2022)

Together, these results suggest a loss of cytotoxic cell function in PBMCs from sAH that may contribute to a decreased ability to communicate with other immune cells, such as monocytes, and prevent the killing of infected cells, thus increasing the risk of infection.

Keyphrases

nk cells
induced apoptosis
cell cycle arrest
early onset
endoplasmic reticulum stress
signaling pathway
peripheral blood
alcohol consumption
drug induced