Risk Stratification of Stage I Grade 3 Endometrioid Endometrial Carcinoma in the Era of Molecular Classification.
William A ZammarrelliSarah H KimArnaud Da Cruz PaulaEric V Rios-DoriaSarah EhmannEffi YeoshouaEtta J HanlonQin C ZhouAlexia IasonosKaled M AlektiarCarol AghajanianVicky MakkerMario M LeitaoNadeem R Abu-RustumLora H EllensonJorge S Reis-FilhoJennifer J MuellerPublished in: JCO precision oncology (2022)
In surgically staged patients with stage I grade 3 EEC, PORTEC-1 and GOG-99 HIR criteria were not prognostic and did not identify CN-H patients. Patients with CN-H EEC had worse PFS and OS compared with those with other molecular subtypes. The integration of the molecular classification with recognized clinicopathologic factors may identify patients with higher-risk stage I grade 3 EEC who benefit from additional therapy.