KDM4A, involved in the inflammatory and oxidative stress caused by traumatic brain injury-hemorrhagic shock, partly through the regulation of the microglia M1 polarization.
Jimin CaiYang YangJiahui HanYu GaoXin LiXin GePublished in: BMC neuroscience (2023)
Accordingly, our findings indicated that KDM4A was upregulated in response to TBI + HS and microglia were among the cell types showing the increased level of KDM4A. The important role of KDM4A in TBI + HS-induced inflammatory response and oxidative stress was at least partially realized through regulating microglia M1 polarization.
Keyphrases
- inflammatory response
- traumatic brain injury
- oxidative stress
- diabetic rats
- lipopolysaccharide induced
- lps induced
- toll like receptor
- neuropathic pain
- severe traumatic brain injury
- dna damage
- ischemia reperfusion injury
- single cell
- induced apoptosis
- high glucose
- cell therapy
- spinal cord injury
- immune response
- drug induced
- endothelial cells
- stress induced
- heat shock