Epidemiology, Risk Factors, and Outcomes After Early Posttransplant Clostridiodes difficile Infection in Renal Transplant Recipients.
Margaret R JorgensonJillian L DescourouezDou-Yan YangGlen E LeversonChristopher M SaddlerJeannina A SmithNasia SafdarDidier A MandlebrotRobert R RedfieldPublished in: The Annals of pharmacotherapy (2019)
Incidence of CDI-90 is low, mostly occurring in the first post-operative month. Risk-factors vary temporally based on time from transplant. In the early post-op period induction agent and age at transplant are significant, but not after. Associations between CDI and negative graft outcomes appear to be largely driven by age. Future studies validating these risk-factors as well as targeted prophylaxis strategies and their effect on long term graft outcomes and the host microbiome are needed.