A multiscale brain network model links Alzheimer's disease-mediated neuronal hyperactivity to large-scale oscillatory slowing.

Anne M van NifterickAlida A GouwRonald E van KesterenPhilip ScheltensCornelis J StamWillem de Haan

Published in: Alzheimer's research & therapy (2022)

Using a computational brain network model, we link findings from different scales and models and support the hypothesis of early-stage neuronal hyperactivity underlying E/I imbalance and whole-brain network dysfunction in prodromal AD.

Keyphrases

cerebral ischemia
early stage
resting state
white matter
functional connectivity
blood brain barrier
high frequency
parkinson disease
radiation therapy