SK2 channels set a signalling hub bolstering CAF-triggered tumourigenic processes in pancreatic cancer.

Raphael Rapetti-Mauss Véronique RigotCamille BerenguierPascal FinettiSarah Simha TubianaBonnie LabrumBenoit AllegriniBernard PellissierGeorgios EfthymiouZainab Hussain Corinne Bousquet Nelson J DusettiFrançois BertucciHélène GuizouarnPatricia MelnykFranck BorgeseRichard Tomasini Olivier Soriani

Published in: Gut (2022)

We establish a new paradigm in which an ion channel shifts the activation level of a signalling pathway in response to stromal cues, opening a new therapeutic window targeting the formation of ion channel-dependent signalling hubs.

Keyphrases

bone marrow
cancer therapy
network analysis
drug delivery
bioinformatics analysis