Flare during tapering of biological DMARDs in patients with rheumatoid arthritis in routine care: characteristics and predictors.
Lene TerslevMikkel OstergaardStylianos GeorgiadisCecilie Heegaard BraheKaren EllegaardU M DohnViktoria FanaTorsten MøllerLars JuulTuan Khai HuynhSimon KrabbeLykke Midtbøll ØrnbjergDaniel GlinatsiHenrik RøgindAnnette HansenJesper NørregaardSøren JacobsenDorte V JensenNatalia ManiloKarsten AsmussenMikael BoesenZoreh RastiemadabadiLone Morsel-CarlsenJakob Møllenbach MøllerNiels Steen KroghMerete Lund HetlandPublished in: RMD open (2022)
The majority of real-world patients with RA tapering bDMARDs flared during tapering, with the majority regaining remission after stepwise dose increase. Demographic and imaging parameters (MR-osteitis/ultrasound greyscale synovitis) were independent predictors of immediate flare and flare overall and may be of importance for clinical decision-making in patients eligible for tapering.
Keyphrases
- end stage renal disease
- chronic kidney disease
- healthcare
- newly diagnosed
- ejection fraction
- magnetic resonance imaging
- high resolution
- rheumatoid arthritis
- palliative care
- magnetic resonance
- prognostic factors
- computed tomography
- patient reported outcomes
- contrast enhanced
- ulcerative colitis
- ultrasound guided
- systemic sclerosis
- photodynamic therapy
- fluorescence imaging
- interstitial lung disease