Spurious laboratory results associated with immunoglobulin M gammopathy in a dog with multiple myeloma.
Samantha C LoaneDaniel A CastilloAnne-Lorraine D M PeschardHarriet R HallAndre J KortumPublished in: Journal of veterinary internal medicine (2022)
An 11 year old female-neutered Labrador presented for facial swelling. Clinicopathological abnormalities included hyperglobulinemia, azotemia, hypercalcemia, nonregenerative anemia, thrombocytopenia, and spurious hypoglycemia. Normoglycemia was subsequently confirmed using a cage-side analyzer (AlphaTRAK, Zoetis, UK). Serum and urine protein electrophoresis documented monoclonal (immunoglobulin M) gammopathy with Bence-Jones proteinuria. Computed tomography imaging revealed a monostotic osteolytic bone-lesion, and bone marrow cytology and histopathology documented plasmacytosis with multiple myeloma oncogene 1 / interferon regulatory factor 4 positivity, consistent with multiple myeloma. Infectious disease testing initially indicated seropositivity for Leishmania, Borrelia, and Anaplasma spp.; however, Leishmania PCR (splenic and bone marrow aspirates), and paired serological titers for Borrelia and Anaplasma were negative. Consequently, initial serological results were considered to be false positive because of paraproteinemia-associated assay interference. Chemotherapy (prednisolone and melphalan combination therapy) was initiated, but the dog was euthanased 30 days later because of the development of pericardial effusion. This is a report of spurious serological (and other laboratory) results occurring secondary to monoclonal gammopathy in a dog.
Keyphrases
- multiple myeloma
- bone marrow
- combination therapy
- computed tomography
- infectious diseases
- mesenchymal stem cells
- type diabetes
- high resolution
- positron emission tomography
- soft tissue
- high dose
- transcription factor
- high throughput
- dendritic cells
- magnetic resonance imaging
- high grade
- bone mineral density
- single cell
- adipose tissue
- fine needle aspiration
- locally advanced
- mass spectrometry
- protein protein
- immune response
- skeletal muscle
- binding protein
- rectal cancer
- insulin resistance
- body composition
- postmenopausal women
- image quality
- chemotherapy induced