Effects of ex vivo blood anticoagulation and preanalytical processing time on the proteome content of platelets.
Samuel Tassi YungaAustin J GowerAlexander R MelroseMeghan K FitzgeraldAshmitha RajendranTheresa A LusardiRandall J ArmstrongJessica MinnierKelley R JordanOwen J T McCartyLarry L DavidPhillip A WilmarthAshok P ReddyJoseph E AslanPublished in: Journal of thrombosis and haemostasis : JTH (2022)
Our results demonstrate that different anticoagulants routinely used for blood collection have varying effects on platelets ex vivo, where methodology-associated alterations in platelet proteome may influence mechanistic, translational and biomarker studies.