Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart.
Yoshinobu NakayamaNobuhiro MukaiGeri KreitzerParth PatwariJun YoshiokaPublished in: Circulation research (2022)
These results uncover a new mechanism of ischemic injury in which ARRDC4 drives glucose deprivation-induced endoplasmic reticulum stress leading to cardiomyocyte death. Our findings establish ARRDC4 as a new scaffold protein for GLUT1 that regulates cardiac metabolism in response to ischemia and provide insight into the therapeutic strategy for ischemic heart disease.
Keyphrases
- endoplasmic reticulum stress
- induced apoptosis
- high glucose
- ischemia reperfusion injury
- cerebral ischemia
- heart failure
- diabetic rats
- left ventricular
- endothelial cells
- angiotensin ii
- protein protein
- drug induced
- amino acid
- binding protein
- adipose tissue
- subarachnoid hemorrhage
- metabolic syndrome
- skeletal muscle
- weight loss