Exploring the therapeutic potential of Sirt6-enriched adipose stem cell-derived exosomes in myocardial ischemia-reperfusion injury: unfolding new epigenetic frontiers.
Kun LiuHecheng WangYiou WangXiaoxu ZhangRuihu WangZhaoxuan ZhangJian WangXinran LuXiaoyu WuYanshuo HanPublished in: Clinical epigenetics (2024)
Our study underscores the potential therapeutic role of Sirt6-enriched exosomes in managing MIRI. We demonstrated their profound cardioprotective effect, evident in the enhanced cardiac function and attenuated tissue damage, through the strategic modulation of AIM2-pyroptosis and mitophagy. Given the intricate interplay between Sirt6 and the aforementioned processes, a comprehensive understanding of these pathways is essential to fully exploit the therapeutic potential of Sirt6. Altogether, our findings indicate the promise of Sirt6-enriched exosomes as a novel therapeutic strategy in treating ischemia-reperfusion injuries and cardiovascular diseases at large. Future research needs to underscore optimizing the balance of mitophagy during myocardial ischemia to avoid potential loss of normal myocytes.
Keyphrases
- ischemia reperfusion injury
- oxidative stress
- stem cells
- mesenchymal stem cells
- cardiovascular disease
- left ventricular
- nlrp inflammasome
- gene expression
- dna methylation
- heart failure
- adipose tissue
- machine learning
- type diabetes
- insulin resistance
- skeletal muscle
- risk assessment
- atrial fibrillation
- cell therapy
- human health
- deep learning