Loss of SMARCB1 promotes autophagy and facilitates tumour progression in chordoma by transcriptionally activating ATG5.

Mingxuan LiYutao ShenYujia XiongShuai WangChuzhong LiJiwei BaiYazhuo Zhang

Published in: Cell proliferation (2021)

Taken together, our results revealed that the SMARCB1/ATG5 axis is a promising therapeutic target for chordoma and autophagy inhibitors may be effective agents for chordoma treatment.

Keyphrases

signaling pathway
cell death
endoplasmic reticulum stress
oxidative stress