Management of Early-Stage Cervical Cancer: A Literature Review.
Yasmin Medeiros GuimarãesLuani Rezende GodoyAdhemar Longatto-FilhoRicardo Dos ReisPublished in: Cancers (2022)
Cervical cancer (CC) remains a public health issue worldwide despite preventive measures. Surgical treatment in the early-stage CC has evolved during the last decades. Our aim was to review the advances in the literature and summarize the ongoing studies on this topic. To this end, we conducted a literature review through PubMed focusing on English-language articles on the surgical management of early-stage CC. The emergent topics considered here are the FIGO 2018 staging system update, conservative management with less radical procedures for selected patients, lymph node staging, fertility preservation, preferred surgical approach, management of tumors up to 2 cm, and prognosis. In terms of updating FIGO, we highlight the inclusion of lymph node status on staging and the possibility of imaging. Regarding the preferred surgical approach, we emphasize the LACC trial impact worldwide in favor of open surgery; however, we discuss the controversial application of this for tumors < 2 cm. In summary, all topics show a tendency to provide patients with tailored treatment that avoids morbidity while maintaining oncologic safety, which is already possible in high-income countries. We believe that efforts should focus on making this a reality for low-income countries as well.
Keyphrases
- lymph node
- early stage
- sentinel lymph node
- public health
- neoadjuvant chemotherapy
- minimally invasive
- end stage renal disease
- case report
- systematic review
- clinical trial
- newly diagnosed
- ejection fraction
- prostate cancer
- chronic kidney disease
- physical activity
- autism spectrum disorder
- squamous cell carcinoma
- patient reported outcomes
- phase ii
- young adults
- atrial fibrillation
- quality improvement
- rectal cancer
- virtual reality
- case control