Dual-Antigen-Displaying Nanovaccines Elicit Synergistic Immunoactivation for Treating Cancer and Preventing Infectious Complications.
Fangjie ChenMengmeng ZhangFengmin YangLu WangJinyao LiuJunqiu LiuYan PangPublished in: Small (Weinheim an der Bergstrasse, Germany) (2023)
As one of the most common complications, infection causes the majority of mortality in cancer patients. However, therapeutic strategies that can simultaneously suppress tumors and protect patients from infection have been rarely reported. Here, the use of dual-antigen-displaying nanovaccines (DADNs) is described to elicit synergistic immunoactivation for treating cancer and preventing infectious complications. DADNs are prepared by wrapping immunoadjuvant-loaded nanoparticles with a hybrid coating, which is fused from cell membranes that are separately genetically engineered to express tumor and infectious pathogenic antigens. Due to the presence of a dual-antigen combination, DADNs are able to promote the maturation of dendritic cells and more importantly to trigger cross-presentation of both combined antigens. During in vivo investigations, we find that DADNs can reverse immunosuppression by stimulating tumor-associated antigen-specific T-cell responses, resulting in significantly delayed tumor growth in mice. These nanovaccines also elicit effective protective immunity against tumor challenges and induce robust production of pathogenic antigen-specific immunoglobulin G antibody in a prophylactic study. This work offers a unique approach to develop dual-mode vaccines, which are promising for synchronously treating cancer and preventing infection.
Keyphrases
- dendritic cells
- papillary thyroid
- risk factors
- squamous cell
- end stage renal disease
- ejection fraction
- cancer therapy
- chronic kidney disease
- immune response
- drug delivery
- squamous cell carcinoma
- newly diagnosed
- cardiovascular disease
- stem cells
- lymph node metastasis
- peritoneal dialysis
- cell therapy
- cardiovascular events
- adipose tissue
- metabolic syndrome
- coronary artery disease
- regulatory t cells
- young adults
- mesenchymal stem cells
- bone marrow