Extramucosal Formation and Prognostic Value of Secretory Antibodies in Rheumatoid Arthritis.

Klara MartinssonLovisa Lyttbacka KlingKarin Roos-LjungbergIrina GriazevaMarina SamoylovichStephane Paul Johan Rönnelid Tomas Weitoft Jonas Wetterö Alf Kastbom

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

Circulating secretory Ig are elevated before and at RA onset. In the presence of free SC, secretory Ig may form outside the mucosa, and SC-containing ACPAs are enriched in RA joints. These findings shed important new light on the mucosal connection in RA development.

Keyphrases

rheumatoid arthritis
disease activity
ankylosing spondylitis
interstitial lung disease
systemic lupus erythematosus
ulcerative colitis