Screening of Pleural Mesothelioma Cell Lines for Kinase Activity May Identify New Mechanisms of Therapy Resistance in Patients Receiving Platin-Based Chemotherapy.
Sabrina BorchertPia-Maria SuckrauMichael WessollyElena MairingerBalazs HegedusThomas HagerThomas HeroldWildfried E E EberhardtJeremias WohlschlaegerClemens AignerAgnes BankfalviKurt Werner SchmidRobert F H WalterFabian Dominik MairingerPublished in: Journal of oncology (2019)
Kinase phosphorylation and activity might play a crucial role in cellular response to cytostatic agents. Cisplatin influences phosphorylation patterns with distinct features in cisplatin-resistant cells. These alterations exert a significant impact on cell cycle, migration, adhesion, signal transduction, immune modulation, and apoptosis of the respective tumor cells. Based on our results, the induction of p38 or JNK1/3, or inhibition of AKT1 by, for example, BIA-6, might offer a positive synergistic effect by induction of an apoptotic response to cisplatin-based treatment, thus potentially enhancing the clinical outcome of MPM patients.
Keyphrases
- cell cycle
- cell death
- cell cycle arrest
- protein kinase
- induced apoptosis
- cell proliferation
- end stage renal disease
- signaling pathway
- endoplasmic reticulum stress
- chronic kidney disease
- ejection fraction
- newly diagnosed
- oxidative stress
- prognostic factors
- tyrosine kinase
- squamous cell carcinoma
- pi k akt
- stem cells
- radiation therapy
- biofilm formation
- anti inflammatory
- bone marrow
- escherichia coli
- pseudomonas aeruginosa
- patient reported
- rectal cancer