Development, characterization, and hematopoietic differentiation of Griscelli syndrome type 2 induced pluripotent stem cells.

Gülen Güney-EskenÖzgür Doğuş ErolBurcu PervinGülben Gürhan SevinçTamer ÖnderElif BilgiçPetek KorkusuzAyşen Günel-ÖzcanDuygu Uçkan-ÇetinkayaFatima S F Aerts-Kaya

Published in: Stem cell research & therapy (2021)

Using the lentiviral transfer of OSKM, we were able to generate different iPSC clones from 3 GS-2 patients. These cells can be used in future studies for the development of novel treatment options and to study the pathophysiology of GS-2 disease.

Keyphrases

induced pluripotent stem cells
end stage renal disease
induced apoptosis
ejection fraction
newly diagnosed
bone marrow
cell cycle arrest
endoplasmic reticulum stress
case report
case control
gene therapy
patient reported