ZEB1 promotes inflammation and progression towards inflammation-driven carcinoma through repression of the DNA repair glycosylase MPG in epithelial cells.

Oriol de BarriosLidia Sanchez-MoralMarlies CortésChiara NinfaliNuria Profitós-PelejàM C Martínez-CampanarioLaura SilesRosa Del CampoMaría Jesús Fernández-AceñeroDouglas S DarlingAntoni CastellsJoan MaurelAzucena SalasDouglas C DeanAntonio Postigo

Published in: Gut (2019)

ZEB1 promotes colitis and inflammatory CRC through the inhibition of MPG in epithelial cells, thus offering new therapeutic strategies to modulate inflammation and inflammatory cancer.

Keyphrases

dna repair
oxidative stress
dna damage
epithelial mesenchymal transition
long non coding rna
dna damage response
papillary thyroid
squamous cell carcinoma
squamous cell
ulcerative colitis