Drug repositioning: diacerein as a new therapeutic approach in a mice model of sciatic nerve injury.

Jhenifer KarvatTassiane Emanuelle Servare AndradeScheila Iria KrausLarissa May BepplerGustavo Dos Santos Catarina de JesusJeane Bachi FerreiraMorgana Duarte da Silva

Published in: Pharmacological reports : PR (2023)

Treatment with DIA reduces hypersensitivity and depression like behaviors in animals. Furthermore, DIA promotes functional recovery and regulates IL-1β and BDNF concentrations.

Keyphrases

drug induced
depressive symptoms
high fat diet induced
type diabetes
emergency department
stress induced
adipose tissue
combination therapy
insulin resistance
adverse drug
smoking cessation