Method Development and Validation for Measuring O6-Methylguanine in Dried Blood Spot Using Ultra High-Performance Liquid Chromatography Tandem Mass Spectrometry.
Yahdiana HarahapAurelia Maria VianneyHerman SuryadiPublished in: Drug design, development and therapy (2021)
The present study has fulfilled the FDA validation parameter requirements. The method provides rapid, sensitive, and selective analysis of O6-methylguanine using UPLC-MS/MS with a linear concentration range between 0.5-20 ng/mL.