Distinct microbes, metabolites, and ecologies define the microbiome in deficient and proficient mismatch repair colorectal cancers.
Vanessa L HalePatricio JeraldoJun ChenMichael MundyJanet YaoSambhawa PriyaGary KeeneyKelly LykeJason RidlonBryan A WhiteAmy J FrenchStephen N ThibodeauChristian DienerOsbaldo Resendis-AntonioJaime GranseeTumpa DuttaXuan-Mai PettersonJaeyun SungRan BlekhmanLisa BoardmanDavid LarsonHeidi NelsonNicholas ChiaPublished in: Genome medicine (2018)
Integrating tumor biology and microbial ecology highlighted distinct microbial, metabolic, and ecological properties unique to dMMR and pMMR CRC. This approach could critically improve our ability to define, predict, prevent, and treat colorectal cancers.