Utility of Plasma Concentration of Trimethylamine N-Oxide in Predicting Cardiovascular and Renal Complications in Individuals With Type 1 Diabetes.
Signe Abitz WintherJens C ØllgaardSimone TheiladeLise TarnowZeneng WangTarunveer S AhluwaliaAnders JorsalSimone TheiladeHans-Henrik ParvingTine W HansenStanley L HazenOluf PedersenPeter RossingPublished in: Diabetes care (2019)
In individuals with type 1 diabetes, higher concentrations of plasma TMAO were associated with mortality, CVD events, and poor renal outcome, independent of conventional risk factors. However, the association became insignificant after further adjustment for baseline eGFR. This could reflect TMAO as a renal function marker or a risk factor for micro- and macrovascular complications mediated through impaired renal function.