Penicillin G concentrations required for prophylaxis against Group A Streptococcus infection evaluated using a hollow fibre model and mathematical modelling.
Jessica R TaitTimothy C BarnettKate E RogersWee Leng LeeMadhu Page-SharpLaurens ManningBen J BoydJonathan R CarapetisRoger L NationCornelia B LandersdorferPublished in: The Journal of antimicrobial chemotherapy (2022)
In the absence of validated animal and human challenge models, the study provides guidance on penicillin G target concentrations for development of new penicillin formulations.