M2 Microglia Extracellular Vesicle miR-124 Regulates Neural Stem Cell Differentiation in Ischemic Stroke via AAK1/NOTCH.
Yaying SongRubing ShiYingjun LiuFengzhen CuiLu HanChuandong WangTingting ChenZongwei LiZhijun ZhangYao-Hui TangYongting WangYang-Tai GuanPublished in: Stroke (2023)
Our data suggest that AAK1/Notch is the key pathway in NSCs that responds to the miR-124 carried within M2-sEVs in the ischemic brain. M2-sEVs carrying ample quantities of miR-124 promote functional recovery after ischemic stroke by enhancing NSC proliferation and differentiation. Targeting of M2-sEVs could represent a potential therapeutic strategy for brain recovery.
Keyphrases
- cell proliferation
- long non coding rna
- stem cells
- long noncoding rna
- resting state
- white matter
- atrial fibrillation
- cerebral ischemia
- signaling pathway
- electronic health record
- functional connectivity
- multiple sclerosis
- cancer therapy
- big data
- machine learning
- oxidative stress
- spinal cord
- deep learning
- artificial intelligence
- data analysis