Extracellular Vesicles Regulate Sympatho-Excitation by Nrf2 in Heart Failure.

Changhai TianLie GaoTara L RudebushLi YuIrving H Zucker

Published in: Circulation research (2022)

Cardiac microRNA-enriched EVs from animals with CHF can mediate crosstalk between the heart and the brain in the regulation of sympathetic outflow by targeting the Nrf2/antioxidant signaling pathway. This new endocrine signaling pathway regulating sympathetic outflow in CHF may be exploited for novel therapeutics.

Keyphrases

signaling pathway
heart failure
oxidative stress
pi k akt
induced apoptosis
left ventricular
epithelial mesenchymal transition
atrial fibrillation
white matter
small molecule
cardiac resynchronization therapy
anti inflammatory
cerebral ischemia
endoplasmic reticulum stress