Assessing known chronic kidney disease associated genetic variants in Saudi Arabian populations.

Cyril CyrusSamir Al-MueiloChittibabu VatteShahanas ChathothYun R LiHatem QutubRudaynah Al AliFahad Al-MuhannaMatthew B LanktreeKhaled Riyad AlkharsahAbdullah Al-RubaishBrian Kim-MozeleskiBrendan KeatingAmein Al Ali

Published in: BMC nephrology (2018)

CKD risk variants identified in European populations are present in Saudis. We did not find evidence to suggest heterogeneity of effect size compared to previously published estimates in European populations. Multivariable logistic regression analysis showed a statistically significant improvement in predicting the CKD using models with either FGF23 and vitamin D or FGF23, vitamin D level, and MYH9 genotypes (AUC = 0.93, 95% CI 0.90-0.95, P < 0.0001).

Keyphrases

chronic kidney disease
end stage renal disease
single cell
gene expression
heart failure
systematic review
atrial fibrillation