Thioredoxin deficiency exacerbates vascular dysfunction during diet-induced obesity in small mesenteric artery in mice.
Shannon DunnRobert H HilgersKumuda C DasPublished in: Microcirculation (New York, N.Y. : 1994) (2020)
Our results indicate that deficiency of active Trx exacerbates MA contractile and relaxing properties during diet-induced obesity demonstrating that loss of redox balance in obesity is a key mechanism of vascular endothelial dysfunction.