The release of GLP-1 from gut L cells is inhibited by low extracellular pH.

Philippa GarbuttMalgorzata CyrankaJohanna MichlYuko MaejimaNatascia VedovatoKenju ShimomuraPawel SwietachHeidi de Wet

Published in: Obesity (Silver Spring, Md.) (2024)

GLP-1 secretion is sensitive to pHe and the buffer present. Exploiting this mechanism therapeutically may benefit patients with obesity.

Keyphrases