Oxidative stress as a possible mechanism of statin-induced myopathy.
Yasin AhmadiAmir GhorbanihaghjoMohsen Naghi-ZadehNeda Lotfi YaginPublished in: Inflammopharmacology (2018)
Statins, inhibitors of hydroxy methyl glutaryl coenzyme-A (HMG-CoA) reductase, are the most widely used drugs for treating hypercholesterolemia. However, statins can cause disabling myopathy as their main adverse effect. Several molecular mechanisms underlie the statin-induced myopathy including the decrease in the levels of essential mevalonate and cholesterol derivatives. This review discusses a further mechanism involving the loss of other anti-oxidant defenses besides ubiquinone (Co-Q) in skeletal muscles which produce a significant amount of reactive oxygen species (ROS). Therefore, to maintain their function, skeletal muscles need a high level of anti-oxidants.
Keyphrases
- reactive oxygen species
- cardiovascular disease
- diabetic rats
- oxidative stress
- late onset
- low density lipoprotein
- high glucose
- coronary artery disease
- drug induced
- muscular dystrophy
- cell death
- type diabetes
- cardiovascular events
- endothelial cells
- emergency department
- ischemia reperfusion injury
- heat shock
- early onset
- induced apoptosis