Combined Metabolic Activators with Different NAD+ Precursors Improve Metabolic Functions in the Animal Models of Neurodegenerative Diseases.
Ozlem AltayHong YangSerkan YıldırımCemil BayramIsmail BolatSena OnerOzlem Ozdemir TozluMehmet Enes ArslanAhmet HacimuftuogluSaeed ShoaieCheng ZhangJan BorénMathias UhlénHasan TurkezAdil MardingluPublished in: Biomedicines (2024)
Our findings suggest that the administration of both CMA1 and CMA2 markedly enhanced metabolic and behavioral outcomes, aligning with neuro-histological observations. These findings underscore the promise of CMA2 administration as an effective therapeutic strategy for enhancing metabolic parameters and cognitive function in AD and PD patients.