Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI.

Elisabeth C van der SlikkeBastiaan S StarMatijs van MeursRobert H HenningJill MoserHjalmar R Bouma

Published in: Critical care (London, England) (2021)

Sepsis-AKI induces mitochondrial DNA damage in the human kidney, without upregulation of mitochondrial quality control mechanisms, which likely resulted in a reduction in mitochondrial mass.

Keyphrases

oxidative stress
dna damage
acute kidney injury
quality control
septic shock
endothelial cells
cell proliferation