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Genome-wide analyses reveal a role of Polycomb in promoting hypomethylation of DNA methylation valleys.

Yuanyuan LiHui ZhengQiujun WangChen ZhouLei WeiXuehui LiuWenhao ZhangYu ZhangZhenhai DuXiaowo WangWei Xie
Published in: Genome biology (2018)
We show that Polycomb promotes the hypomethylation of DMVs near key developmental genes. These data reveal a delicate interplay between histone modifiers and DNA methylation, which contributes to their division at distinct gene targets, allowing lineage-specifying genes to largely maintain DNA methylation-free at regulatory elements.
Keyphrases
  • genome wide
  • dna methylation
  • copy number
  • gene expression
  • transcription factor
  • single cell
  • electronic health record
  • big data
  • deep learning
  • genome wide identification