Genome-wide analyses reveal a role of Polycomb in promoting hypomethylation of DNA methylation valleys.
Yuanyuan LiHui ZhengQiujun WangChen ZhouLei WeiXuehui LiuWenhao ZhangYu ZhangZhenhai DuXiaowo WangWei XiePublished in: Genome biology (2018)
We show that Polycomb promotes the hypomethylation of DMVs near key developmental genes. These data reveal a delicate interplay between histone modifiers and DNA methylation, which contributes to their division at distinct gene targets, allowing lineage-specifying genes to largely maintain DNA methylation-free at regulatory elements.